General description

Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows anti-proliferative effect on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic acid moieties with trans-peroxynitrous acid.

Parenteral iron chelating agent. Commonly used in therapy as a chelator of ferric iron in disorders of iron overload. Completely protects against dopamine-induced cell death. Has also been shown to interfere with hydroxyl radical formation, which mediates tissue damage in several disease states. Shows antiproliferative effects on vascular smooth muscle cells in vitro and in vivo. Can also inhibit the oxidative chemistry of peroxynitrite by reaction of the hydroxamic moieties with trans-peroxynitrous acid.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bergeron, R.J., et al. 1996. J. Med. Chem. 39, 1575.Ben-Shachar, D., et al. 1995. J. Neurochem. 64, 718.Denicola, A., et al. 1995. Free Radic. Biol. Med. 19, 11.Dzwigaj, S., and pererat, H., 1995. Free Radic. Res.14, 103.Dang, S., et al. 1994. Res. Commun. Mol. Pathol. Pharmacol. 86, 43.Porreca, E., et al. 1994. Arterioscler. Thromb. 14, 299.

Packaging

1 g in Plastic ampoule

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)